@article{JSS3789,
author = {Stephan Duetzmann and Ulrich Pilatus and Volker Seifert and Gerhard Marquardt and Matthias Setzer},
title = { Ex vivo 1H MR spectroscopy and histology after experimental chronic spinal cord compression},
journal = {Journal of Spine Surgery},
volume = {3},
number = {2},
year = {2017},
keywords = {},
abstract = {Background: Proton magnetic resonance imaging (MRS) is used increasingly to image the spinal cord in compressive cervical myelopathy (CSM). However, detailed analyses of the underlying histomorphological changes leading to MRS alterations are still lacking. The aim of our study was to correlate neuroimaging and neuropathologic alterations in a rabbit myelopathy model.
Methods: Chronic spinal cord compression was induced in a rabbit model (n=16) allowing for a gradual 270° compression of the spinal cord. Spinal cord compression core areas were divided into two samples for (A) 1H MRS and (B) histopathological analyses. Postoperatively the animals underwent a neurological examination twice a day and outcome was categorized in pattern of injury and amount of recovery.
Results: Three groups were observed and categorized: (I) animals with severe deficits and no or minimal recovery; (II) animals with severe deficits and complete or almost complete recovery; (III) animals with mild to moderate deficits and a complete recovery. Significant differences in the lesioned spinal cords between the different recovery groups were found for N-acetyl-aspartate and choline. NAA/Cr was detected significantly (P},
issn = {2414-4630}, url = {https://jss.amegroups.org/article/view/3789}
}